Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL753458

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibitory activity against Plasmodium falciparum
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Expert

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and antiprotozoal activity of aza-analogues of furamidine.
Ismail MA, Brun R, Easterbrook JD, Tanious FA, Wilson WD, Boykin DW.
J Med Chem (2003) 46 : 4761 -4769
PubMed 14561095 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 6.21 8.41

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL145572 1 8.41
CHEMBL145251 1 8.19
CHEMBL144893 1 8.06
CHEMBL24057 FURAMIDINE -1.0 1 7.81
CHEMBL424121 1 7.74
CHEMBL358287 1 7.08
CHEMBL141719 1 6.83
CHEMBL344103 1 5.37
CHEMBL356072 1 5.31
CHEMBL264664 1 5.31
CHEMBL357661 1 5.14
CHEMBL146273 1 5.07
CHEMBL145118 1 4.99
CHEMBL144950 1 4.88
CHEMBL145654 1 4.75
CHEMBL145627 1 4.38
CHEMBL146548 1 -
CHEMBL343253 1 -
CHEMBL342961 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL145572 IC50 = 3.9 nM 8.41
CHEMBL145251 IC50 = 6.5 nM 8.19
CHEMBL144893 IC50 = 8.8 nM 8.06
CHEMBL24057 FURAMIDINE IC50 = 15.5 nM 7.81
CHEMBL424121 IC50 = 18.3 nM 7.74
CHEMBL358287 IC50 = 83.0 nM 7.08
CHEMBL141719 IC50 = 148.0 nM 6.83
CHEMBL344103 IC50 = 4300.0 nM 5.37
CHEMBL356072 IC50 = 4900.0 nM 5.31
CHEMBL264664 IC50 = 4900.0 nM 5.31
CHEMBL357661 IC50 = 7300.0 nM 5.14
CHEMBL146273 IC50 = 8500.0 nM 5.07
CHEMBL145118 IC50 = 10200.0 nM 4.99
CHEMBL144950 IC50 = 13100.0 nM 4.88
CHEMBL145654 IC50 = 17700.0 nM 4.75
CHEMBL145627 IC50 = 41500.0 nM 4.38
CHEMBL146548 IC50 > 11700.0 nM -
CHEMBL343253 IC50 > 10400.0 nM -
CHEMBL342961 IC50 > 10500.0 nM -