Assay Detail
Binding
CHEMBL753510
Review assay metadata, readout intent, target linkage, and publication context from the same page.
High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity model
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.94 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.00 |
| CHEMBL347534 | — | — | 1 | 7.00 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.70 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 6.52 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 6.22 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 5.92 |
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 5.58 |
| CHEMBL152371 | PAFENOLOL | 2.0 | 1 | 5.26 |
| CHEMBL170 | QUININE | 4.0 | 1 | 4.92 |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 4.32 |
| CHEMBL13 | METOPROLOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL347534 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL6966 | VERAPAMIL | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL157101 | KETOCONAZOLE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL1294 | QUINIDINE | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL152371 | PAFENOLOL | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL170 | QUININE | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL27 | PROPRANOLOL | Ki | = | 48000.0 | nM | 4.32 |
| CHEMBL13 | METOPROLOL | Ki | = | 200000.0 | nM | - |