Assay Detail
Binding
CHEMBL753520
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Binding inhibition against opioid receptor kappa of guinea pig was determined using [3H]ethylketocyclazocine
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis, opioid receptor binding profile, and antinociceptive activity of 1-azaspiro[4.5]decan-10-yl amides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.14 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279065 | — | — | 1 | 6.98 |
| CHEMBL22211 | — | — | 1 | 6.51 |
| CHEMBL553991 | — | — | 1 | 6.17 |
| CHEMBL553062 | — | — | 1 | 6.17 |
| CHEMBL277202 | — | — | 1 | 6.06 |
| CHEMBL22569 | — | — | 1 | 5.55 |
| CHEMBL25386 | — | — | 1 | 5.55 |
| CHEMBL554212 | — | — | 1 | - |
| CHEMBL544684 | — | — | 1 | - |
| CHEMBL282244 | — | — | 1 | - |
| CHEMBL553782 | — | — | 1 | - |
| CHEMBL22458 | — | — | 1 | - |
| CHEMBL23016 | — | — | 1 | - |
| CHEMBL542069 | — | — | 1 | - |
| CHEMBL542564 | — | — | 1 | - |
| CHEMBL23777 | — | — | 1 | - |
| CHEMBL539228 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279065 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL22211 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL553991 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL553062 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL277202 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL22569 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL25386 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL554212 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL544684 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL282244 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL553782 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL22458 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL23016 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL542069 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL542564 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL23777 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL539228 | — | IC50 | > | 10000.0 | nM | - |