Assay Detail
Binding
CHEMBL753555
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for binding affinity towards kappa opioid receptor in guinea pig cerebellar membrane using [3H]bremazocine
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebellum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and opioid activity of dynorphin A-(1-13)NH2 analogues containing cis- and trans-4-aminocyclohexanecarboxylic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.26 | 9.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415330 | — | — | 1 | 9.84 |
| CHEMBL2369477 | — | — | 2 | 8.04 |
| CHEMBL404976 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415330 | — | Ki | = | 0.146 | nM | 9.84 |
| CHEMBL2369477 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL2369477 | — | Ki | = | 13.4 | nM | 7.87 |
| CHEMBL404976 | — | Ki | = | 50.0 | nM | 7.30 |