Assay Detail
Binding
CHEMBL753563
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Concentration that produces 50% inhibition of stereospecific [3H]naloxone binding to opioid receptors in rat brain in presence of sodium.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Assessment of the in vivo and in vitro opioid activity of bridged hexahydroaporphine and isoquinoline molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.27 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2062261 | — | — | 1 | 7.24 |
| CHEMBL556578 | MORPHINE HYDROCHLORIDE | 3.0 | 1 | 6.31 |
| CHEMBL81058 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2062261 | — | IC50 | = | 57.4 | nM | 7.24 |
| CHEMBL556578 | MORPHINE HYDROCHLORIDE | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL81058 | — | IC50 | = | 5590.0 | nM | 5.25 |