Assay Detail
Binding
CHEMBL753643
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Inhibition of [125I]- NGF binding to extracellular domain of p75 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Tumor necrosis factor receptor superfamily member 16 (CHEMBL4762) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Kynurenic acid derivatives inhibit the binding of nerve growth factor (NGF) to the low-affinity p75 NGF receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.94 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137953 | — | — | 1 | 6.70 |
| CHEMBL136617 | — | — | 1 | 5.89 |
| CHEMBL342150 | — | — | 1 | 5.64 |
| CHEMBL139216 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137953 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL136617 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL342150 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL139216 | — | IC50 | = | 3100.0 | nM | 5.51 |