Compound Detail
CHEMBL136617
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Basic Information
| ChEMBL ID | CHEMBL136617 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KWZZQZGQOBABNS-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
334.3
MW (Da)
0.47
ALogP
10
HBA
2
HBD
132.1
PSA (Ų)
0.66
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tumor necrosis factor receptor superfamily member 16 CHEMBL4762 | IC50 | 5.89 | 5.89 | 1300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tumor necrosis factor receptor superfamily member 16 | IC50 | = | 1300.0 | nM | 5.89 | Inhibition of [125I]- NGF binding to extracellular domain of p75 receptor | 7473570 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7473570 | 10.1021/jm00022a008 | Tumor necrosis factor receptor superfamily member 16 | 1 |
Data from ChEMBL 36 via Core Engine