Assay Detail
Binding
CHEMBL753712
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Compound was tested for its inhibition against human OSC enzyme
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A novel series of 4-piperidinopyridine and 4-piperidinopyrimidine inhibitors of 2,3-oxidosqualene cyclase-lanosterol synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.09 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25405 | — | — | 1 | 7.46 |
| CHEMBL70223 | — | — | 1 | 7.43 |
| CHEMBL359233 | — | — | 1 | 6.95 |
| CHEMBL148378 | — | — | 1 | 6.84 |
| CHEMBL70222 | — | — | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25405 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL70223 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL359233 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL148378 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL70222 | — | IC50 | = | 161.0 | nM | 6.79 |