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Assay Detail

CHEMBL753724

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue
ChEMBL ↗
163
Total Activities
159
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Oxytocin receptor (CHEMBL3996) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Nanomolar-affinity, non-peptide oxytocin receptor antagonists.
Evans BE, Lundell GF, Gilbert KF, Bock MG, Rittle KE, Carroll LA, Williams PD, Pawluczyk JM, Leighton JL, Young MB.
J Med Chem (1993) 36 : 3993 -4005
PubMed 8258821 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 163 7.10 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL338711 — — 1 9.15
CHEMBL131477 — — 1 8.92
CHEMBL338921 — — 1 8.77
CHEMBL336082 — — 1 8.66
CHEMBL339929 — — 1 8.64
CHEMBL130891 — — 1 8.59
CHEMBL433662 — — 1 8.49
CHEMBL339498 — — 1 8.39
CHEMBL338984 — — 1 8.38
CHEMBL128749 — — 1 8.31
CHEMBL339768 — — 1 8.23
CHEMBL339756 — — 1 8.22
CHEMBL128219 — — 1 8.20
CHEMBL339524 — — 1 8.17
CHEMBL436189 — — 1 8.12
CHEMBL337889 — — 1 8.08
CHEMBL339497 — — 2 7.96
CHEMBL435019 — — 1 7.96
CHEMBL341049 — — 1 7.92
CHEMBL130742 — — 1 7.92
CHEMBL2112666 — — 1 7.92
CHEMBL128258 — — 1 7.89
CHEMBL341289 — — 3 7.89
CHEMBL405016 — — 1 7.89
CHEMBL128712 — — 1 7.85
CHEMBL339132 — — 1 7.85
CHEMBL338576 — — 1 7.80
CHEMBL338383 — — 1 7.75
CHEMBL340388 — — 1 7.72
CHEMBL128383 — — 1 7.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL338711 — IC50 = 0.7 nM 9.15
CHEMBL131477 — IC50 = 1.2 nM 8.92
CHEMBL338921 — IC50 = 1.7 nM 8.77
CHEMBL336082 — IC50 = 2.2 nM 8.66
CHEMBL339929 — IC50 = 2.3 nM 8.64
CHEMBL130891 — IC50 = 2.6 nM 8.59
CHEMBL433662 — IC50 = 3.2 nM 8.49
CHEMBL339498 — IC50 = 4.1 nM 8.39
CHEMBL338984 — IC50 = 4.2 nM 8.38
CHEMBL128749 — IC50 = 4.9 nM 8.31
CHEMBL339768 — IC50 = 5.9 nM 8.23
CHEMBL339756 — IC50 = 6.0 nM 8.22
CHEMBL128219 — IC50 = 6.3 nM 8.20
CHEMBL339524 — IC50 = 6.7 nM 8.17
CHEMBL436189 — IC50 = 7.6 nM 8.12
CHEMBL337889 — IC50 = 8.3 nM 8.08
CHEMBL339497 — IC50 = 11.0 nM 7.96
CHEMBL435019 — IC50 = 11.0 nM 7.96
CHEMBL339497 — IC50 = 11.0 nM 7.96
CHEMBL130742 — IC50 = 12.0 nM 7.92
CHEMBL341049 — IC50 = 12.0 nM 7.92
CHEMBL2112666 — IC50 = 12.0 nM 7.92
CHEMBL128258 — IC50 = 13.0 nM 7.89
CHEMBL405016 — IC50 = 13.0 nM 7.89
CHEMBL341289 — IC50 = 13.0 nM 7.89
CHEMBL339132 — IC50 = 14.0 nM 7.85
CHEMBL128712 — IC50 = 14.0 nM 7.85
CHEMBL341289 — IC50 = 15.0 nM 7.82
CHEMBL341289 — IC50 = 16.0 nM 7.80
CHEMBL338576 — IC50 = 16.0 nM 7.80
CHEMBL338383 — IC50 = 18.0 nM 7.75
CHEMBL340388 — IC50 = 19.0 nM 7.72
CHEMBL128383 — IC50 = 20.0 nM 7.70
CHEMBL129983 — IC50 = 21.0 nM 7.68
CHEMBL435409 — IC50 = 23.0 nM 7.64
CHEMBL335886 — IC50 = 27.0 nM 7.57
CHEMBL335944 — IC50 = 29.0 nM 7.54
CHEMBL132157 — IC50 = 30.0 nM 7.52
CHEMBL337221 — IC50 = 30.0 nM 7.52
CHEMBL338951 — IC50 = 30.0 nM 7.52
CHEMBL339155 — IC50 = 30.0 nM 7.52
CHEMBL265073 — IC50 = 32.0 nM 7.50
CHEMBL128652 — IC50 = 32.0 nM 7.50
CHEMBL335182 — IC50 = 35.0 nM 7.46
CHEMBL130905 — IC50 = 35.0 nM 7.46
CHEMBL130476 — IC50 = 36.0 nM 7.44
CHEMBL132210 — IC50 = 37.0 nM 7.43
CHEMBL340639 — IC50 = 38.0 nM 7.42
CHEMBL2112663 — IC50 = 40.0 nM 7.40
CHEMBL338503 — IC50 = 42.0 nM 7.38