Assay Detail
Binding
CHEMBL753746
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Opioid receptor mu 1 using [3H]DAMGO as radioligand.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Enantiomers of diastereomeric cis-N-[1-(2-hydroxy-2-phenylethyl)- 3-methyl-4-piperidyl]-N-phenylpropanamides: synthesis, X-ray analysis, and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.67 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2373217 | — | — | 1 | 10.89 |
| CHEMBL38685 | — | — | 1 | 10.70 |
| CHEMBL596 | FENTANYL | 4.0 | 1 | 8.40 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.09 |
| CHEMBL2373216 | — | — | 1 | 7.78 |
| CHEMBL290411 | — | — | 1 | 7.51 |
| CHEMBL2373185 | — | — | 1 | 7.33 |
| CHEMBL2373184 | — | — | 1 | - |
| CHEMBL544473 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2373217 | — | Ki | = | 0.013 | nM | 10.89 |
| CHEMBL38685 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL596 | FENTANYL | Ki | = | 3.97 | nM | 8.40 |
| CHEMBL70 | MORPHINE | Ki | = | 8.14 | nM | 8.09 |
| CHEMBL2373216 | — | Ki | = | 16.47 | nM | 7.78 |
| CHEMBL290411 | — | Ki | = | 30.6 | nM | 7.51 |
| CHEMBL2373185 | — | Ki | = | 47.07 | nM | 7.33 |
| CHEMBL2373184 | — | Ki | = | 0.005 | nM | - |
| CHEMBL544473 | — | Ki | = | 0.0055 | nM | - |