Assay Detail
Binding
CHEMBL753842
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for binding affinity of Opioid receptor kappa 1 in guinea pig brain membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
An approach to the design of receptor-type-selective non-peptide antagonists of peptidergic receptors: delta opioid antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.00 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 7.70 |
| CHEMBL100940 | NALTRIBEN | — | 1 | 6.82 |
| CHEMBL567175 | NALTRINDOLE | — | 1 | 6.48 |
| CHEMBL47545 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19019 | NALTREXONE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL100940 | NALTRIBEN | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL567175 | NALTRINDOLE | Ki | = | 332.0 | nM | 6.48 |
| CHEMBL47545 | — | Ki | > | 1000.0 | nM | - |