Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL753849

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]- DAGO from opioid receptor mu in rat brain membrane
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Brain
Subcellular Membrane
Confidence 9 — Direct single protein target
Curated By Expert

Target

Mu-type opioid receptor (CHEMBL270)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and structure-activity relationships of deltorphin analogues.
Salvadori S, Marastoni M, Balboni G, Borea PA, Morari M, Tomatis R.
J Med Chem (1991) 34 : 1656 -1661
PubMed 1851843 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.44 8.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL278789 DERMORPHIN 1 8.49
CHEMBL70 MORPHINE 4.0 1 8.41
CHEMBL44172 1 7.00
CHEMBL296749 1 6.80
CHEMBL297059 1 6.44
CHEMBL297567 1 6.42
CHEMBL46540 1 6.35
CHEMBL294982 1 6.19
CHEMBL47156 1 6.18
CHEMBL295076 1 6.16
CHEMBL281140 1 6.04
CHEMBL32202 1 5.92
CHEMBL45308 1 5.82
CHEMBL29078 1 5.50
CHEMBL296603 DELTORPHINE II 1 4.84

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL278789 DERMORPHIN IC50 = 3.2 nM 8.49
CHEMBL70 MORPHINE IC50 = 3.9 nM 8.41
CHEMBL44172 IC50 = 100.0 nM 7.00
CHEMBL296749 IC50 = 158.0 nM 6.80
CHEMBL297059 IC50 = 360.0 nM 6.44
CHEMBL297567 IC50 = 380.0 nM 6.42
CHEMBL46540 IC50 = 450.0 nM 6.35
CHEMBL294982 IC50 = 640.0 nM 6.19
CHEMBL47156 IC50 = 660.0 nM 6.18
CHEMBL295076 IC50 = 700.0 nM 6.16
CHEMBL281140 IC50 = 910.0 nM 6.04
CHEMBL32202 IC50 = 1200.0 nM 5.92
CHEMBL45308 IC50 = 1500.0 nM 5.82
CHEMBL29078 IC50 = 3200.0 nM 5.50
CHEMBL296603 DELTORPHINE II IC50 = 14500.0 nM 4.84