Assay Detail
Binding
CHEMBL753915
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Binding affinity against Opioid receptor kappa 1 isolated from rat brain membrane was determined using [3H]U-69593 as radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 14-alkoxymorphinans. 20. 14-phenylpropoxymetopon: an extremely powerful analgesic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.43 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL133836 | DIHYDROETORPHINE | — | 1 | 9.89 |
| CHEMBL140050 | ETORPHINE | 2.0 | 1 | 9.74 |
| CHEMBL335969 | — | — | 1 | 9.40 |
| CHEMBL337272 | — | — | 1 | 8.65 |
| CHEMBL334511 | — | — | 1 | 7.62 |
| CHEMBL134067 | — | — | 1 | 7.60 |
| CHEMBL133454 | — | — | 1 | 7.57 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133836 | DIHYDROETORPHINE | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL140050 | ETORPHINE | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL335969 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL337272 | — | Ki | = | 2.26 | nM | 8.65 |
| CHEMBL334511 | — | Ki | = | 24.1 | nM | 7.62 |
| CHEMBL134067 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL133454 | — | Ki | = | 26.9 | nM | 7.57 |
| CHEMBL70 | MORPHINE | Ki | = | 113.0 | nM | 6.95 |