Assay Detail
Binding
CHEMBL753918
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Ability to inhibit the specific binding of [3H]- dihydromorphine to opiate receptors in rat brain membrane preparation by 50%
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Combined analgesic/neuroleptic activity in N-butyrophenone prodine-like compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.87 | 8.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299471 | — | — | 1 | 8.53 |
| CHEMBL292006 | — | — | 1 | 8.48 |
| CHEMBL56547 | — | — | 1 | 8.06 |
| CHEMBL1160253 | — | — | 1 | 7.63 |
| CHEMBL57306 | — | — | 1 | 6.22 |
| CHEMBL54206 | — | — | 1 | 5.49 |
| CHEMBL59213 | — | — | 1 | 5.26 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 5.25 |
| CHEMBL56843 | — | — | 1 | - |
| CHEMBL57029 | — | — | 1 | - |
| CHEMBL57140 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299471 | — | IC50 | = | 2.96 | nM | 8.53 |
| CHEMBL292006 | — | IC50 | = | 3.33 | nM | 8.48 |
| CHEMBL56547 | — | IC50 | = | 8.67 | nM | 8.06 |
| CHEMBL1160253 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL57306 | — | IC50 | = | 598.0 | nM | 6.22 |
| CHEMBL54206 | — | IC50 | = | 3215.0 | nM | 5.49 |
| CHEMBL59213 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 5687.0 | nM | 5.25 |
| CHEMBL56843 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL57029 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL57140 | — | IC50 | > | 10000.0 | nM | - |