Assay Detail
Binding
CHEMBL753952
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Ability to displace [3H]DAMGO from mu opioid receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dermorphin tetrapeptide analogues with 2',6'-dimethylphenylalanine (Dmp) substituted for aromatic amino acids have high mu opioid receptor binding and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 9.65 | 10.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24059 | — | — | 1 | 10.67 |
| CHEMBL23836 | — | — | 1 | 10.46 |
| CHEMBL23133 | — | — | 1 | 10.21 |
| CHEMBL280178 | — | — | 1 | 10.21 |
| CHEMBL22321 | — | — | 1 | 9.76 |
| CHEMBL23325 | — | — | 1 | 8.14 |
| CHEMBL23295 | — | — | 1 | 8.12 |
| CHEMBL23362 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24059 | — | Ki | = | 0.0216 | nM | 10.67 |
| CHEMBL23836 | — | Ki | = | 0.035 | nM | 10.46 |
| CHEMBL23133 | — | Ki | = | 0.0618 | nM | 10.21 |
| CHEMBL280178 | — | Ki | = | 0.0623 | nM | 10.21 |
| CHEMBL22321 | — | Ki | = | 0.172 | nM | 9.76 |
| CHEMBL23325 | — | Ki | = | 7.17 | nM | 8.14 |
| CHEMBL23295 | — | Ki | = | 7.62 | nM | 8.12 |
| CHEMBL23362 | — | Ki | = | 0.00205 | nM | - |