Assay Detail
Binding
CHEMBL753955
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]naloxone from the Opioid receptor mu 1 isolated from the rat brain membranes.
25
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of a series of new 3-methyl-1,4-disubstituted-piperidine analgesics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 8.86 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL327270 | — | — | 1 | 9.89 |
| CHEMBL431047 | — | — | 1 | 9.82 |
| CHEMBL319060 | — | — | 2 | 9.72 |
| CHEMBL658 | SUFENTANIL | 4.0 | 1 | 9.66 |
| CHEMBL95247 | — | — | 2 | 9.52 |
| CHEMBL318958 | — | — | 2 | 9.48 |
| CHEMBL95248 | — | — | 1 | 9.11 |
| CHEMBL95909 | — | — | 1 | 8.96 |
| CHEMBL95390 | — | — | 2 | 8.70 |
| CHEMBL95786 | — | — | 1 | 8.70 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.68 |
| CHEMBL596 | FENTANYL | 4.0 | 1 | 8.67 |
| CHEMBL319343 | — | — | 1 | 8.67 |
| CHEMBL318895 | — | — | 1 | 8.55 |
| CHEMBL100111 | — | — | 2 | 8.38 |
| CHEMBL329950 | — | — | 1 | 8.12 |
| CHEMBL634 | ALFENTANIL | 4.0 | 1 | 8.09 |
| CHEMBL99596 | — | — | 1 | 8.09 |
| CHEMBL317822 | — | — | 1 | 7.95 |
| CHEMBL316670 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL327270 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL431047 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL319060 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL658 | SUFENTANIL | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL95247 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL318958 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL95247 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL95248 | — | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL318958 | — | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL319060 | — | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL95909 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL95786 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL95390 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL70 | MORPHINE | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL319343 | — | Ki | = | 2.16 | nM | 8.67 |
| CHEMBL596 | FENTANYL | Ki | = | 2.16 | nM | 8.67 |
| CHEMBL318895 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL100111 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL329950 | — | Ki | = | 7.62 | nM | 8.12 |
| CHEMBL99596 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL634 | ALFENTANIL | Ki | = | 8.21 | nM | 8.09 |
| CHEMBL317822 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL100111 | — | Ki | = | 32.2 | nM | 7.49 |
| CHEMBL316670 | — | Ki | > | 100.0 | nM | - |
| CHEMBL95390 | — | Ki | > | 1000.0 | nM | - |