Assay Detail
Binding
CHEMBL753956
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Ability to inhibit [3H]DAMGO binding to rat brain Opioid receptor mu 1
26
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
(E)-8-benzylidene derivatives of 2-methyl-5-(3-hydroxyphenyl)morphans: highly selective ligands for the sigma 2 receptor subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 7.78 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145780 | — | — | 1 | 8.66 |
| CHEMBL143800 | — | — | 3 | 8.41 |
| CHEMBL322468 | — | — | 3 | 8.35 |
| CHEMBL141381 | — | — | 3 | 8.19 |
| CHEMBL38791 | — | — | 2 | 8.06 |
| CHEMBL356639 | — | — | 1 | 8.04 |
| CHEMBL358527 | — | — | 1 | 7.95 |
| CHEMBL145296 | — | — | 3 | 7.93 |
| CHEMBL146659 | — | — | 3 | 7.93 |
| CHEMBL145422 | — | — | 1 | 7.57 |
| CHEMBL110319 | — | — | 3 | 7.47 |
| CHEMBL109124 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145780 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL143800 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL143800 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL322468 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL322468 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL141381 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL38791 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL356639 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL358527 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL146659 | — | Ki | = | 11.8 | nM | 7.93 |
| CHEMBL145296 | — | Ki | = | 11.8 | nM | 7.93 |
| CHEMBL145296 | — | Ki | = | 12.6 | nM | 7.90 |
| CHEMBL141381 | — | Ki | = | 21.6 | nM | 7.67 |
| CHEMBL146659 | — | Ki | = | 23.2 | nM | 7.63 |
| CHEMBL145422 | — | Ki | = | 26.7 | nM | 7.57 |
| CHEMBL143800 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL145296 | — | Ki | = | 31.4 | nM | 7.50 |
| CHEMBL110319 | — | Ki | = | 33.9 | nM | 7.47 |
| CHEMBL38791 | — | Ki | = | 35.5 | nM | 7.45 |
| CHEMBL110319 | — | Ki | = | 37.6 | nM | 7.42 |
| CHEMBL322468 | — | Ki | = | 45.1 | nM | 7.35 |
| CHEMBL146659 | — | Ki | = | 47.6 | nM | 7.32 |
| CHEMBL141381 | — | Ki | = | 48.2 | nM | 7.32 |
| CHEMBL110319 | — | Ki | = | 392.0 | nM | 6.41 |
| CHEMBL109124 | — | Ki | > | 250.0 | nM | - |
| CHEMBL109124 | — | Ki | > | 250.0 | nM | - |