Assay Detail
Binding
CHEMBL753958
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Affinity against Opioid receptor mu 1 was determined by measuring the inhibition of [3H]DAMGO binding to rat forebrain membranes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.99 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384584 | — | — | 1 | 9.62 |
| CHEMBL406893 | — | — | 1 | 8.41 |
| CHEMBL442323 | — | — | 1 | 8.02 |
| CHEMBL406338 | — | — | 1 | 7.96 |
| CHEMBL268818 | — | — | 1 | 7.51 |
| CHEMBL266782 | — | — | 1 | 7.50 |
| CHEMBL267215 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384584 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL406893 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL442323 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL406338 | — | Ki | = | 10.9 | nM | 7.96 |
| CHEMBL268818 | — | Ki | = | 31.1 | nM | 7.51 |
| CHEMBL266782 | — | Ki | = | 31.7 | nM | 7.50 |
| CHEMBL267215 | — | Ki | = | 128.0 | nM | 6.89 |