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Assay Detail

CHEMBL754073

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro growth inhibition of Plasmodium falciparum FcB1R
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Expert

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Antiplasmodial activity and cytotoxicity of bis-, tris-, and tetraquinolines with linear or cyclic amino linkers.
Girault S, Grellier P, Berecibar A, Maes L, Lemière P, Mouray E, Davioud-Charvet E, Sergheraert C.
J Med Chem (2001) 44 : 1658 -1665
PubMed 11356101 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 7.11 7.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL448417 1 7.74
CHEMBL386396 1 7.65
CHEMBL405238 1 7.49
CHEMBL289194 1 7.42
CHEMBL384639 1 7.11
CHEMBL279113 1 7.10
CHEMBL47585 1 7.09
CHEMBL295589 1 6.99
CHEMBL47534 1 6.96
CHEMBL46736 1 6.95
CHEMBL298436 1 6.82
CHEMBL408541 1 6.58
CHEMBL296917 1 6.56
CHEMBL44872 1 -
CHEMBL45031 1 -
CHEMBL46617 1 -
CHEMBL297227 1 -
CHEMBL44947 1 -
CHEMBL47163 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL448417 IC50 = 18.3 nM 7.74
CHEMBL386396 IC50 = 22.6 nM 7.65
CHEMBL405238 IC50 = 32.7 nM 7.49
CHEMBL289194 IC50 = 38.1 nM 7.42
CHEMBL384639 IC50 = 76.9 nM 7.11
CHEMBL279113 IC50 = 79.1 nM 7.10
CHEMBL47585 IC50 = 81.1 nM 7.09
CHEMBL295589 IC50 = 102.6 nM 6.99
CHEMBL47534 IC50 = 108.8 nM 6.96
CHEMBL46736 IC50 = 112.8 nM 6.95
CHEMBL298436 IC50 = 152.2 nM 6.82
CHEMBL408541 IC50 = 266.2 nM 6.58
CHEMBL296917 IC50 = 274.7 nM 6.56
CHEMBL44872 IC50 > 1000.0 nM -
CHEMBL45031 IC50 > 1000.0 nM -
CHEMBL46617 IC50 > 1000.0 nM -
CHEMBL297227 IC50 > 1000.0 nM -
CHEMBL44947 IC50 > 1000.0 nM -
CHEMBL47163 IC50 > 1000.0 nM -