Compound Detail
CHEMBL289194
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O=C(CCC(=O)N1CCN(c2ccnc3cc(Cl)ccc23)CCN(c2ccnc3cc(Cl)ccc23)CC1)N1CCN(c2ccnc3cc(Cl)ccc23)CCN(c2ccnc3cc(Cl)ccc23)CC1
Basic Information
| ChEMBL ID | CHEMBL289194 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JWDFMODBYORBJO-UHFFFAOYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
986.8
MW (Da)
10.28
ALogP
10
HBA
0
HBD
105.1
PSA (Ų)
0.15
QED
2
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 7.66 | 7.5575 | 21.9 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 21.9 | nM | 7.66 | In vitro growth inhibition of Plasmodium falciparum D6 | 11356101 |
| Plasmodium falciparum | IC50 | = | 23.7 | nM | 7.62 | In vitro growth inhibition of Plasmodium falciparum F32 | 11356101 |
| Plasmodium falciparum | IC50 | = | 29.5 | nM | 7.53 | In vitro growth inhibition of Plasmodium falciparum W2 | 11356101 |
| Plasmodium falciparum | IC50 | = | 38.1 | nM | 7.42 | In vitro growth inhibition of Plasmodium falciparum FcB1R | 11356101 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11356101 | 10.1021/jm001096a | Plasmodium falciparum | 4 |
| 11356101 | 10.1021/jm001096a | MRC5 | 4 |
| 11356101 | 10.1021/jm001096a | ADMET | 3 |
Data from ChEMBL 36 via Core Engine