Assay Detail
Functional
CHEMBL754076
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluated the ability to protect against the irreversible antagonism of morphines effects by beta-FNA in guinea pig ileal longitudinal muscle.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Muscle tissue |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Different receptor sites mediate opioid agonism and antagonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.11 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140050 | ETORPHINE | 2.0 | 1 | 9.52 |
| CHEMBL278086 | ETHYLKETAZOCINE | — | 1 | 9.22 |
| CHEMBL283440 | — | — | 1 | 7.68 |
| CHEMBL413090 | — | — | 1 | 7.66 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.62 |
| CHEMBL415284 | NALORPHINE | 2.0 | 1 | 7.55 |
| CHEMBL282137 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140050 | ETORPHINE | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL278086 | ETHYLKETAZOCINE | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL283440 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL413090 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL70 | MORPHINE | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL415284 | NALORPHINE | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL282137 | — | IC50 | = | 28.0 | nM | 7.55 |