Compound Detail
CHEMBL278086
ETHYLKETAZOCINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL278086 |
| Name | ETHYLKETAZOCINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VVPXGTRPIKVDOV-UHFFFAOYSA-N |
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
313.4
MW (Da)
3.66
ALogP
3
HBA
0
HBD
29.5
PSA (Ų)
0.85
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 9.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Opioid receptors; mu/kappa/delta CHEMBL2095181 | IC50 | 9.22 | 9.22 | 0.6 | 1 |
| Cavia porcellus CHEMBL369 | IC50 | 9.16 | 8.824 | 0.7 | 5 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Opioid receptors; mu/kappa/delta | IC50 | = | 0.6 | nM | 9.22 | Evaluated the ability to protect against the irreversible antagonism of morphine... | 6312042 |
| Cavia porcellus | IC50 | = | 0.69 | nM | 9.16 | Agonistic effect on beta-FNA treated guinea pig ileum preparations (GPI) | 6300401 |
| Cavia porcellus | IC50 | = | 0.72 | nM | 9.14 | Agonistic effect on untreated guinea pig ileum preparations (GPI) | 6300401 |
| Cavia porcellus | IC50 | = | 0.973 | nM | 9.01 | Irreversible antagonistic potency in guinea pig ileal longitudinal muscle (GPI) | 6310111 |
| Cavia porcellus | IC50 | = | 1.6 | nM | 8.8 | Agonist activity in guinea pig ileum preparation | 6207298 |
| Cavia porcellus | IC50 | = | 9.73 | nM | 8.01 | Evaluated for the inhibition concentration in the guinea pig ileal longitudinal ... | 6090663 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 6300401 | 10.1021/jm00358a009 | Cavia porcellus | 2 |
| 6300401 | 10.1021/jm00358a009 | Unchecked | 2 |
| 6207298 | 10.1021/jm00376a026 | Cavia porcellus | 1 |
| 6310111 | 10.1021/jm00363a005 | Cavia porcellus | 1 |
| 6090663 | 10.1021/jm00376a018 | Cavia porcellus | 1 |
| 6312042 | 10.1021/jm00364a001 | Unchecked | 1 |
| 6312042 | 10.1021/jm00364a001 | Opioid receptors; mu/kappa/delta | 1 |
Data from ChEMBL 36 via Core Engine