Assay Detail

CHEMBL684109

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Functional

Agonistic effect on untreated guinea pig ileum preparations (GPI)

ChEMBL ↗

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Target

Cavia porcellus (CHEMBL369) ↗

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Primary target Cavia porcellus

CHEMBL369

Anchored from Assay target.

Protein identity Cavia porcellus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Cavia porcellus
Tissue	Ileum
Confidence	1 — Organism
Curated By	Intermediate

Target

Cavia porcellus (CHEMBL369) ↗

Type	ORGANISM
Organism	Cavia porcellus

Publication

Alkylation of opioid receptor subtypes by alpha-chlornaltrexamine produces concurrent irreversible agonistic and irreversible antagonistic activities.

Sayre LM, Takemori AE, Portoghese PS.
J Med Chem (1983) 26 : 503 -506
PubMed 6300401 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.70	9.14

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL278086	ETHYLKETAZOCINE	—	1	9.14
CHEMBL357323	—	—	1	8.26

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL278086	ETHYLKETAZOCINE	IC50	=	0.72	nM	9.14
CHEMBL357323	—	IC50	=	5.5	nM	8.26