Assay Detail
Binding
CHEMBL754083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for binding affinity on intact HEK cells using [3H]diprenorphine as radioligand singly expressed with delta or kappa receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.85 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409172 | — | — | 1 | 8.96 |
| CHEMBL414603 | — | — | 1 | 8.48 |
| CHEMBL440626 | — | — | 1 | 7.26 |
| CHEMBL410574 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409172 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL414603 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL440626 | — | Ki | = | 54.8 | nM | 7.26 |
| CHEMBL410574 | — | Ki | = | 199.0 | nM | 6.70 |