Assay Detail
Binding
CHEMBL754165
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In vitro inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in accumulation assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of new templates derived from pyrrolopyrimidine as selective multidrug-resistance-associated protein inhibitors in multidrug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.91 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27128 | — | — | 1 | 5.48 |
| CHEMBL29743 | — | — | 1 | 5.21 |
| CHEMBL285343 | — | — | 1 | 5.16 |
| CHEMBL29631 | — | — | 1 | 5.16 |
| CHEMBL431503 | — | — | 1 | 5.08 |
| CHEMBL26081 | — | — | 1 | 5.08 |
| CHEMBL284024 | — | — | 1 | 5.08 |
| CHEMBL25867 | — | — | 1 | 5.04 |
| CHEMBL27536 | — | — | 1 | 5.04 |
| CHEMBL30052 | — | — | 1 | 5.00 |
| CHEMBL26039 | — | — | 1 | 4.98 |
| CHEMBL430925 | — | — | 1 | 4.94 |
| CHEMBL283693 | — | — | 1 | 4.84 |
| CHEMBL28584 | — | — | 1 | 4.76 |
| CHEMBL282156 | — | — | 1 | 4.74 |
| CHEMBL26369 | — | — | 1 | 4.67 |
| CHEMBL430724 | — | — | 1 | 4.65 |
| CHEMBL281235 | — | — | 1 | 4.61 |
| CHEMBL283438 | — | — | 1 | 4.55 |
| CHEMBL25972 | — | — | 1 | 4.55 |
| CHEMBL27257 | — | — | 1 | 4.40 |
| CHEMBL287181 | — | — | 1 | - |
| CHEMBL281284 | — | — | 1 | - |
| CHEMBL281743 | — | — | 1 | - |
| CHEMBL27191 | — | — | 1 | - |
| CHEMBL286963 | — | — | 1 | - |
| CHEMBL283255 | — | — | 1 | - |
| CHEMBL439727 | — | — | 1 | - |
| CHEMBL26678 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27128 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL29743 | — | IC50 | = | 6140.0 | nM | 5.21 |
| CHEMBL285343 | — | IC50 | = | 6940.0 | nM | 5.16 |
| CHEMBL29631 | — | IC50 | = | 6940.0 | nM | 5.16 |
| CHEMBL431503 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL26081 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL284024 | — | IC50 | = | 8220.0 | nM | 5.08 |
| CHEMBL25867 | — | IC50 | = | 9230.0 | nM | 5.04 |
| CHEMBL27536 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL30052 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL26039 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL430925 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL283693 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL28584 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL282156 | — | IC50 | = | 18040.0 | nM | 4.74 |
| CHEMBL26369 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL430724 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL281235 | — | IC50 | = | 24550.0 | nM | 4.61 |
| CHEMBL283438 | — | IC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL25972 | — | IC50 | = | 27860.0 | nM | 4.55 |
| CHEMBL27257 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL287181 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL281284 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL281743 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL27191 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL286963 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL283255 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL439727 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL26678 | — | IC50 | > | 40000.0 | nM | - |