Assay Detail
Binding
CHEMBL754205
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Binding affinity by inhibition of [3H]DAMGO binding to Opioid receptor mu 1 from rat brain membranes
45
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and binding affinities of 4-diarylaminotropanes, a new class of delta opioid agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 45 | 6.16 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.74 |
| CHEMBL13169 | — | — | 1 | 7.89 |
| CHEMBL12752 | — | — | 1 | 7.64 |
| CHEMBL275011 | — | — | 1 | 7.03 |
| CHEMBL13414 | — | — | 1 | 6.95 |
| CHEMBL275135 | — | — | 1 | 6.91 |
| CHEMBL13309 | — | — | 1 | 6.89 |
| CHEMBL275288 | — | — | 1 | 6.89 |
| CHEMBL13479 | — | — | 1 | 6.76 |
| CHEMBL274167 | — | — | 1 | 6.61 |
| CHEMBL273929 | — | — | 1 | 6.60 |
| CHEMBL13327 | — | — | 2 | 6.53 |
| CHEMBL273404 | — | — | 1 | 6.51 |
| CHEMBL13371 | — | — | 1 | 6.46 |
| CHEMBL268941 | — | — | 1 | 6.43 |
| CHEMBL13301 | — | — | 1 | 6.43 |
| CHEMBL264948 | — | — | 1 | 6.15 |
| CHEMBL13691 | — | — | 1 | 6.09 |
| CHEMBL13725 | — | — | 1 | 6.09 |
| CHEMBL13493 | — | — | 1 | 6.07 |
| CHEMBL13292 | — | — | 1 | 6.01 |
| CHEMBL13403 | — | — | 1 | 5.94 |
| CHEMBL13055 | — | — | 1 | 5.93 |
| CHEMBL276243 | — | — | 1 | 5.92 |
| CHEMBL13470 | SNC-80 | — | 1 | 5.89 |
| CHEMBL13360 | — | — | 1 | 5.87 |
| CHEMBL406783 | — | — | 1 | 5.85 |
| CHEMBL12828 | — | — | 1 | 5.85 |
| CHEMBL13393 | — | — | 1 | 5.80 |
| CHEMBL13454 | — | — | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70 | MORPHINE | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL13169 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL12752 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL275011 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL13414 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL275135 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL275288 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL13309 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL13479 | — | Ki | = | 172.0 | nM | 6.76 |
| CHEMBL274167 | — | Ki | = | 244.0 | nM | 6.61 |
| CHEMBL273929 | — | Ki | = | 249.0 | nM | 6.60 |
| CHEMBL13327 | — | Ki | = | 293.0 | nM | 6.53 |
| CHEMBL13327 | — | Ki | = | 308.0 | nM | 6.51 |
| CHEMBL273404 | — | Ki | = | 311.0 | nM | 6.51 |
| CHEMBL13371 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL268941 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL13301 | — | Ki | = | 371.0 | nM | 6.43 |
| CHEMBL264948 | — | Ki | = | 704.0 | nM | 6.15 |
| CHEMBL13725 | — | Ki | = | 817.0 | nM | 6.09 |
| CHEMBL13691 | — | Ki | = | 818.0 | nM | 6.09 |
| CHEMBL13493 | — | Ki | = | 845.0 | nM | 6.07 |
| CHEMBL13292 | — | Ki | = | 975.0 | nM | 6.01 |
| CHEMBL13403 | — | Ki | = | 1155.0 | nM | 5.94 |
| CHEMBL13055 | — | Ki | = | 1185.0 | nM | 5.93 |
| CHEMBL276243 | — | Ki | = | 1205.0 | nM | 5.92 |
| CHEMBL13470 | SNC-80 | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL13360 | — | Ki | = | 1343.0 | nM | 5.87 |
| CHEMBL12828 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL406783 | — | Ki | = | 1420.0 | nM | 5.85 |
| CHEMBL13393 | — | Ki | = | 1590.0 | nM | 5.80 |
| CHEMBL13454 | — | Ki | = | 1725.0 | nM | 5.76 |
| CHEMBL269697 | — | Ki | = | 1820.0 | nM | 5.74 |
| CHEMBL12765 | — | Ki | = | 1850.0 | nM | 5.73 |
| CHEMBL13616 | — | Ki | = | 2525.0 | nM | 5.60 |
| CHEMBL274650 | — | Ki | = | 2773.0 | nM | 5.56 |
| CHEMBL268981 | — | Ki | = | 2770.0 | nM | 5.56 |
| CHEMBL13420 | — | Ki | = | 2950.0 | nM | 5.53 |
| CHEMBL13374 | — | Ki | = | 3018.0 | nM | 5.52 |
| CHEMBL12912 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL13316 | — | Ki | = | 4346.0 | nM | 5.36 |
| CHEMBL13143 | — | Ki | = | 4830.0 | nM | 5.32 |
| CHEMBL274125 | — | Ki | = | 5040.0 | nM | 5.30 |
| CHEMBL13286 | — | Ki | = | 5790.0 | nM | 5.24 |
| CHEMBL13146 | — | Ki | = | 6350.0 | nM | 5.20 |
| CHEMBL441905 | — | Ki | = | 7500.0 | nM | 5.12 |