Assay Detail
Binding
CHEMBL754238
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Concentration required to inhibit [3H]naltrexone binding to Opioid receptors
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and pharmacology of metabolically stable tert-butyl ethers of morphine and levorphanol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.09 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.57 |
| CHEMBL22207 | RACEMETHORPHAN | 2.0 | 1 | 5.70 |
| CHEMBL485 | CODEINE | 4.0 | 1 | 5.00 |
| CHEMBL22919 | — | — | 1 | - |
| CHEMBL280688 | — | — | 1 | - |
| CHEMBL592 | LEVORPHANOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70 | MORPHINE | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL22207 | RACEMETHORPHAN | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL485 | CODEINE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL22919 | — | IC50 | = | 20000.0 | — | - |
| CHEMBL280688 | — | IC50 | = | 3000.0 | — | - |
| CHEMBL592 | LEVORPHANOL | IC50 | = | 4000.0 | — | - |