Assay Detail
Binding
CHEMBL754239
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Concentration required to inhibit the stereospecific [3H]diprenorphine binding Opioid receptors in the absence of sodium(Na+) was determined in mouse isolated vas deferens
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
N-Methylnalorphine: definition of N-allyl conformation for antagonism at the opiate receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.22 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415284 | NALORPHINE | 2.0 | 1 | 7.23 |
| CHEMBL610906 | — | — | 2 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415284 | NALORPHINE | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL610906 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL610906 | — | IC50 | = | 8500.0 | nM | 5.07 |