Assay Detail
Functional
CHEMBL754241
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Opioid receptors antagonist activity in smooth-muscle tissue mouse vas deferens (MVD)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Vas deferens |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design and synthesis of highly potent and selective cyclic dynorphin A analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.20 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415330 | — | — | 1 | 8.11 |
| CHEMBL410616 | — | — | 1 | 7.71 |
| CHEMBL443068 | — | — | 1 | 7.70 |
| CHEMBL411557 | DYNORPHIN A (1-17) | — | 1 | 7.65 |
| CHEMBL384250 | — | — | 1 | 7.61 |
| CHEMBL216640 | — | — | 1 | 6.69 |
| CHEMBL385759 | — | — | 1 | 6.38 |
| CHEMBL265824 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415330 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL410616 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL443068 | — | IC50 | = | 20.1 | nM | 7.70 |
| CHEMBL411557 | DYNORPHIN A (1-17) | IC50 | = | 22.5 | nM | 7.65 |
| CHEMBL384250 | — | IC50 | = | 24.5 | nM | 7.61 |
| CHEMBL216640 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL385759 | — | IC50 | = | 421.0 | nM | 6.38 |
| CHEMBL265824 | — | IC50 | = | 1660.0 | nM | 5.78 |