Assay Detail
Functional
CHEMBL754251
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In vitro biological activity by electrically induced smooth muscle contractions in mouse vas deferens (Opioid receptor delta 1); inhibitory concentration was evaluated
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dermorphin and deltorphin heptapeptide analogues: replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.16 | 10.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169860 | — | — | 1 | 10.66 |
| CHEMBL317956 | DELTORPHIN C | — | 1 | 9.23 |
| CHEMBL355178 | — | — | 1 | 8.34 |
| CHEMBL278789 | DERMORPHIN | — | 1 | 7.46 |
| CHEMBL169439 | — | — | 1 | 6.84 |
| CHEMBL168110 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169860 | — | IC50 | = | 0.022 | nM | 10.66 |
| CHEMBL317956 | DELTORPHIN C | IC50 | = | 0.582 | nM | 9.23 |
| CHEMBL355178 | — | IC50 | = | 4.62 | nM | 8.34 |
| CHEMBL278789 | DERMORPHIN | IC50 | = | 34.4 | nM | 7.46 |
| CHEMBL169439 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL168110 | — | IC50 | = | 358.0 | nM | 6.45 |