Assay Detail
Functional
CHEMBL754286
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the agonistic activity against Opioid receptor delta 1 in hamster vas deferens.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activities of dynorphin A analogues with opioid antagonist properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.04 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2028997 | — | — | 1 | 6.58 |
| CHEMBL438223 | DYNORPHIN A (1-11) | — | 1 | 6.55 |
| CHEMBL2373009 | — | — | 1 | 6.14 |
| CHEMBL384584 | — | — | 1 | 6.03 |
| CHEMBL2373013 | — | — | 1 | 5.57 |
| CHEMBL2373014 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2028997 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL438223 | DYNORPHIN A (1-11) | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL2373009 | — | IC50 | = | 717.0 | nM | 6.14 |
| CHEMBL384584 | — | IC50 | = | 929.0 | nM | 6.03 |
| CHEMBL2373013 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL2373014 | — | IC50 | = | 4320.0 | nM | 5.37 |