Compound Detail
CHEMBL438223
DYNORPHIN A (1-11) Enter ChEMBL ID:
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CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)O
Basic Information
| ChEMBL ID | CHEMBL438223 |
| Name | DYNORPHIN A (1-11) |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | WZHQALIQGVYQGG-QFIUEGLPSA-N |
8
Targets
16
Activities
2
Assay Types
4
PK Parameters
19
Publications
0
Known Names
Molecular Properties
1362.7
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 9 meas. best 10.11
Ki 7 meas. best 9.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Kappa-type opioid receptor CHEMBL3952 | IC50 | 10.11 | 10.11 | 0.1 | 1 |
| Kappa-type opioid receptor CHEMBL237 | IC50 | 9.96 | 8.92 | 0.1 | 2 |
| Kappa-type opioid receptor CHEMBL237 | Ki | 9.92 | 9.92 | 0.1 | 1 |
| Kappa-type opioid receptor CHEMBL3952 | Ki | 9.89 | 9.89 | 0.1 | 1 |
| Mu-type opioid receptor CHEMBL4354 | IC50 | 8.97 | 8.6433 | 1.1 | 3 |
| Kappa-type opioid receptor CHEMBL3614 | Ki | 8.96 | 8.96 | 1.1 | 1 |
| Mu-type opioid receptor CHEMBL270 | Ki | 8.57 | 8.515 | 2.7 | 2 |
| Delta-type opioid receptor CHEMBL236 | IC50 | 8.16 | 7.355 | 7.0 | 2 |
| Delta-type opioid receptor CHEMBL3222 | Ki | 8.09 | 8.09 | 8.2 | 1 |
| Delta-type opioid receptor CHEMBL269 | Ki | 7.97 | 7.97 | 10.7 | 1 |
| Delta-type opioid receptor CHEMBL3222 | IC50 | 7.54 | 7.54 | 28.9 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Ke | - | - | Cavia porcellus |
| Ke | - | - | Cricetulus griseus |
| Ke | - | - | Oryctolagus cuniculus |
| T1/2 | 0.7 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2876099 | 10.1021/jm00160a019 | Delta-type opioid receptor | 4 |
| 2876099 | 10.1021/jm00160a019 | Kappa-type opioid receptor | 4 |
| 2876099 | 10.1021/jm00160a019 | Mu-type opioid receptor | 4 |
| 8096246 | 10.1021/jm00058a012 | Opioid receptors; mu & kappa | 2 |
| 27797517 | 10.1021/acs.jmedchem.6b01411 | Kappa-type opioid receptor | 2 |
| 19807094 | 10.1021/jm900715m | Unchecked | 2 |
| 8096246 | 10.1021/jm00058a012 | Delta-type opioid receptor | 2 |
| 8096246 | 10.1021/jm00058a012 | Mu-type opioid receptor | 2 |
| 8096246 | 10.1021/jm00058a012 | Kappa-type opioid receptor | 1 |
| 2876099 | 10.1021/jm00160a019 | Oryctolagus cuniculus | 1 |
| 8096246 | 10.1021/jm00058a012 | Opioid receptors; delta & kappa | 1 |
| 2876099 | 10.1021/jm00160a019 | Cricetinae gen. sp. | 1 |
| 19807094 | 10.1021/jm900715m | Delta-type opioid receptor | 1 |
| 19807094 | 10.1021/jm900715m | Mu-type opioid receptor | 1 |
| 19807094 | 10.1021/jm900715m | Kappa-type opioid receptor | 1 |
| 2876099 | 10.1021/jm00160a019 | Cavia porcellus | 1 |
| 27797517 | 10.1021/acs.jmedchem.6b01411 | Mu-type opioid receptor | 1 |
| 27797517 | 10.1021/acs.jmedchem.6b01411 | Delta-type opioid receptor | 1 |
| 27797517 | 10.1021/acs.jmedchem.6b01411 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine