Assay Detail
Binding
CHEMBL844035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]DPDPE binding to delta opioid receptor of guinea pig brain homogenate
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.78 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265241 | — | — | 1 | 9.32 |
| CHEMBL438274 | — | — | 1 | 8.71 |
| CHEMBL411557 | DYNORPHIN A (1-17) | — | 1 | 8.60 |
| CHEMBL405618 | ANALOG OF DYNORPHIN A | — | 1 | 8.39 |
| CHEMBL409793 | — | — | 1 | 8.18 |
| CHEMBL438223 | DYNORPHIN A (1-11) | — | 1 | 8.16 |
| CHEMBL411196 | — | — | 1 | 8.02 |
| CHEMBL386722 | — | — | 1 | 7.51 |
| CHEMBL444626 | — | — | 1 | 7.08 |
| CHEMBL414494 | — | — | 1 | 7.06 |
| CHEMBL384566 | — | — | 1 | 6.97 |
| CHEMBL2371443 | — | — | 1 | 6.74 |
| CHEMBL408497 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265241 | — | IC50 | = | 0.475 | nM | 9.32 |
| CHEMBL438274 | — | IC50 | = | 1.93 | nM | 8.71 |
| CHEMBL411557 | DYNORPHIN A (1-17) | IC50 | = | 2.54 | nM | 8.60 |
| CHEMBL405618 | ANALOG OF DYNORPHIN A | IC50 | = | 4.07 | nM | 8.39 |
| CHEMBL409793 | — | IC50 | = | 6.54 | nM | 8.18 |
| CHEMBL438223 | DYNORPHIN A (1-11) | IC50 | = | 6.99 | nM | 8.16 |
| CHEMBL411196 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL386722 | — | IC50 | = | 31.2 | nM | 7.51 |
| CHEMBL444626 | — | IC50 | = | 82.5 | nM | 7.08 |
| CHEMBL414494 | — | IC50 | = | 86.3 | nM | 7.06 |
| CHEMBL384566 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL2371443 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL408497 | — | IC50 | = | 389.0 | nM | 6.41 |