Assay Detail
Functional
CHEMBL757522
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the agonistic activity against Opioid receptor mu 1 in guinea pig ileum.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological activities of dynorphin A analogues with opioid antagonist properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.71 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2028997 | — | — | 1 | 9.55 |
| CHEMBL2373009 | — | — | 1 | 8.55 |
| CHEMBL438223 | DYNORPHIN A (1-11) | — | 1 | 8.54 |
| CHEMBL384584 | — | — | 1 | 8.48 |
| CHEMBL2373014 | — | — | 1 | 7.16 |
| CHEMBL3037891 | — | — | 1 | 6.65 |
| CHEMBL2373012 | — | — | 1 | 5.05 |
| CHEMBL2373008 | — | — | 1 | - |
| CHEMBL2373013 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2028997 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL2373009 | — | IC50 | = | 2.84 | nM | 8.55 |
| CHEMBL438223 | DYNORPHIN A (1-11) | IC50 | = | 2.88 | nM | 8.54 |
| CHEMBL384584 | — | IC50 | = | 3.32 | nM | 8.48 |
| CHEMBL2373014 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL3037891 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL2373012 | — | IC50 | = | 8890.0 | nM | 5.05 |
| CHEMBL2373008 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2373013 | — | IC50 | > | 10000.0 | nM | - |