Assay Detail
Binding
CHEMBL845237
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Inhibition of delta-selective antagonist binding to opioid receptor of mouse vas dferens
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.85 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405618 | ANALOG OF DYNORPHIN A | — | 1 | 8.04 |
| CHEMBL438274 | — | — | 1 | 8.04 |
| CHEMBL409793 | — | — | 1 | 7.60 |
| CHEMBL438223 | DYNORPHIN A (1-11) | — | 1 | 7.54 |
| CHEMBL411557 | DYNORPHIN A (1-17) | — | 1 | 7.40 |
| CHEMBL265241 | — | — | 1 | 7.03 |
| CHEMBL411196 | — | — | 1 | 5.39 |
| CHEMBL2371443 | — | — | 1 | 5.38 |
| CHEMBL415406 | — | — | 1 | 5.20 |
| CHEMBL384566 | — | — | 1 | - |
| CHEMBL386722 | — | — | 1 | - |
| CHEMBL408497 | — | — | 1 | - |
| CHEMBL414494 | — | — | 1 | - |
| CHEMBL444626 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405618 | ANALOG OF DYNORPHIN A | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL438274 | — | IC50 | = | 9.17 | nM | 8.04 |
| CHEMBL409793 | — | IC50 | = | 25.3 | nM | 7.60 |
| CHEMBL438223 | DYNORPHIN A (1-11) | IC50 | = | 28.93 | nM | 7.54 |
| CHEMBL411557 | DYNORPHIN A (1-17) | IC50 | = | 39.7 | nM | 7.40 |
| CHEMBL265241 | — | IC50 | = | 92.6 | nM | 7.03 |
| CHEMBL411196 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL2371443 | — | IC50 | = | 4180.0 | nM | 5.38 |
| CHEMBL415406 | — | IC50 | = | 6262.0 | nM | 5.20 |
| CHEMBL384566 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL386722 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL408497 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL414494 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL444626 | — | IC50 | > | 3000.0 | nM | - |