Assay Detail
Binding
CHEMBL754444
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the inhibition of [3H]DSLET([[3H]D-Ser2,Leu5,Thr6]enkephalin binding to Opioid receptor delta 1 in rat brain homogenates.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activities of dynorphin A analogues with opioid antagonist properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.16 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2373009 | — | — | 1 | 8.27 |
| CHEMBL2028997 | — | — | 1 | 8.20 |
| CHEMBL384584 | — | — | 1 | 8.13 |
| CHEMBL438223 | DYNORPHIN A (1-11) | — | 1 | 7.97 |
| CHEMBL2373013 | — | — | 1 | 6.87 |
| CHEMBL2373014 | — | — | 1 | 6.52 |
| CHEMBL2373012 | — | — | 1 | 6.25 |
| CHEMBL2373008 | — | — | 1 | 6.20 |
| CHEMBL3037891 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2373009 | — | Ki | = | 5.43 | nM | 8.27 |
| CHEMBL2028997 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL384584 | — | Ki | = | 7.47 | nM | 8.13 |
| CHEMBL438223 | DYNORPHIN A (1-11) | Ki | = | 10.66 | nM | 7.97 |
| CHEMBL2373013 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL2373014 | — | Ki | = | 303.0 | nM | 6.52 |
| CHEMBL2373012 | — | Ki | = | 561.0 | nM | 6.25 |
| CHEMBL2373008 | — | Ki | = | 631.0 | nM | 6.20 |
| CHEMBL3037891 | — | Ki | = | 1035.0 | nM | 5.99 |