Assay Detail
Binding
CHEMBL754345
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IC50 was measured as binding to rat cortex membranes using [3H]- NT(neurotensin) as tracer
11
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Ketomethylene and (cyanomethylene)amino pseudopeptide analogues of the C-terminal hexapeptide of neurotensin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.65 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1793839 | — | — | 1 | 8.30 |
| CHEMBL2371276 | — | — | 1 | 8.10 |
| CHEMBL342252 | — | — | 1 | 8.00 |
| CHEMBL3143334 | — | — | 2 | 7.82 |
| CHEMBL3143232 | — | — | 4 | 6.92 |
| CHEMBL1793838 | — | — | 1 | 5.20 |
| CHEMBL1793837 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1793839 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2371276 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL342252 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3143334 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3143232 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3143232 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3143334 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3143232 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3143232 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1793838 | — | IC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL1793837 | — | IC50 | = | 8000.0 | nM | 5.10 |