Assay Detail
Binding
CHEMBL754350
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Neurotensin receptor binding affinity by displacement of [3H]- neurotensin
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Stable isosteres of neurotensin c-terminal pentapeptides derived by modification of the amide function
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.12 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8857 | — | — | 1 | 7.20 |
| CHEMBL427656 | — | — | 1 | 7.09 |
| CHEMBL2372106 | — | — | 1 | 6.93 |
| CHEMBL8454 | — | — | 1 | 6.16 |
| CHEMBL275752 | — | — | 1 | 5.79 |
| CHEMBL267748 | — | — | 1 | 5.79 |
| CHEMBL8899 | — | — | 1 | 5.53 |
| CHEMBL429903 | — | — | 1 | 5.41 |
| CHEMBL409061 | — | — | 1 | 5.22 |
| CHEMBL269581 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8857 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL427656 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL2372106 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL8454 | — | Ki | = | 688.0 | nM | 6.16 |
| CHEMBL275752 | — | Ki | = | 1607.0 | nM | 5.79 |
| CHEMBL267748 | — | Ki | = | 1626.0 | nM | 5.79 |
| CHEMBL8899 | — | Ki | = | 2985.0 | nM | 5.53 |
| CHEMBL429903 | — | Ki | = | 3857.0 | nM | 5.41 |
| CHEMBL409061 | — | Ki | = | 5958.0 | nM | 5.22 |
| CHEMBL269581 | — | Ki | > | 10000.0 | nM | - |