Assay Detail
Binding
CHEMBL754357
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In vitro inhibition of Neutral Endopeptidase isolated from rat kidney.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Dual metalloprotease inhibitors. IV. Utilization of thiazepines and thiazines as constrained peptidomimetic surrogates in mercaptoacyl dipeptides
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.04 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69836 | — | — | 1 | 9.05 |
| CHEMBL51780 | — | — | 1 | 9.00 |
| CHEMBL305020 | — | — | 1 | 8.62 |
| CHEMBL305050 | — | — | 1 | 8.60 |
| CHEMBL71769 | — | — | 1 | 8.57 |
| CHEMBL304148 | — | — | 1 | 7.40 |
| CHEMBL298388 | — | — | 1 | 7.19 |
| CHEMBL68849 | — | — | 1 | 7.00 |
| CHEMBL71711 | — | — | 1 | 6.90 |
| CHEMBL306461 | — | — | 1 | 6.61 |
| CHEMBL71496 | — | — | 1 | 6.60 |
| CHEMBL71746 | — | — | 1 | 6.42 |
| CHEMBL67804 | — | — | 1 | 6.27 |
| CHEMBL71538 | — | — | 1 | 5.87 |
| CHEMBL71351 | — | — | 1 | 5.81 |
| CHEMBL420192 | — | — | 1 | 5.70 |
| CHEMBL306938 | — | — | 1 | 5.69 |
| CHEMBL67924 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69836 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL51780 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL305020 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL305050 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL71769 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL304148 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL298388 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL68849 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL71711 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL306461 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL71496 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL71746 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL67804 | — | IC50 | = | 535.0 | nM | 6.27 |
| CHEMBL71538 | — | IC50 | = | 1352.0 | nM | 5.87 |
| CHEMBL71351 | — | IC50 | = | 1559.0 | nM | 5.81 |
| CHEMBL420192 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL306938 | — | IC50 | = | 2043.0 | nM | 5.69 |
| CHEMBL67924 | — | IC50 | = | 3820.0 | nM | 5.42 |