Assay Detail
Binding
CHEMBL754452
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Opioid receptor kappa 1 apparent binding constant from guinea pig cerebellum using [3H]diprenorphine binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebellum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Photoactivatable opiate derivatives as irreversible probes of the mu-opioid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.97 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314209 | — | — | 1 | 9.15 |
| CHEMBL311995 | NALTREXONEDIAZONIUM | — | 1 | 9.00 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 8.06 |
| CHEMBL290429 | CARFENTANIL | 2.0 | 1 | 7.04 |
| CHEMBL310829 | — | — | 1 | 6.62 |
| CHEMBL81328 | — | — | 1 | - |
| CHEMBL309542 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314209 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL311995 | NALTREXONEDIAZONIUM | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL19019 | NALTREXONE | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL290429 | CARFENTANIL | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL310829 | — | Ki | = | 242.0 | nM | 6.62 |
| CHEMBL81328 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL309542 | — | Ki | > | 10000.0 | nM | - |