Assay Detail
Binding
CHEMBL754512
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Inhibition of neuronal nitric oxide synthase (nNOS) in mice
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.71 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105792 | — | — | 1 | 7.82 |
| CHEMBL447832 | — | — | 1 | 6.40 |
| CHEMBL227744 | NITROARGININE | 1.0 | 1 | 6.30 |
| CHEMBL106261 | — | — | 1 | 6.24 |
| CHEMBL317459 | — | — | 1 | 6.17 |
| CHEMBL320547 | — | — | 1 | 6.10 |
| CHEMBL323117 | — | — | 1 | 6.07 |
| CHEMBL108318 | — | — | 1 | 6.04 |
| CHEMBL108319 | — | — | 1 | 5.92 |
| CHEMBL107413 | — | — | 1 | 5.85 |
| CHEMBL110789 | — | — | 1 | 5.80 |
| CHEMBL110705 | — | — | 1 | 5.77 |
| CHEMBL108352 | — | — | 1 | 5.75 |
| CHEMBL105830 | — | — | 1 | 5.64 |
| CHEMBL105820 | — | — | 1 | 5.60 |
| CHEMBL108788 | — | — | 1 | 5.55 |
| CHEMBL107404 | — | — | 1 | 5.44 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 5.37 |
| CHEMBL105823 | — | — | 1 | 5.01 |
| CHEMBL69446 | — | — | 1 | 4.47 |
| CHEMBL322085 | — | — | 1 | 4.24 |
| CHEMBL110498 | — | — | 1 | 4.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105792 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL447832 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL227744 | NITROARGININE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL106261 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL317459 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL320547 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL323117 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL108318 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL108319 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL107413 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL110789 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL110705 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL108352 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL105830 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL105820 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL108788 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL107404 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL256147 | TILARGININE | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL105823 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL69446 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL322085 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL110498 | — | IC50 | = | 73000.0 | nM | 4.14 |