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Assay Detail

CHEMBL754534

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of p38 alpha-2 kinase
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Mitogen-activated protein kinase 14 (CHEMBL260)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

p38 kinase inhibitors for the treatment of arthritis and osteoporosis: thienyl, furyl, and pyrrolyl ureas.
Redman AM, Johnson JS, Dally R, Swartz S, Wild H, Paulsen H, Caringal Y, Gunn D, Renick J, Osterhout M, Kingery-Wood J, Smith RA, Lee W, Dumas J, Wilhelm SM, Housley TJ, Bhargava A, Ranges GE, Shrikhande A, Young D, Bombara M, Scott WJ.
Bioorg Med Chem Lett (2001) 11 : 9 -12
PubMed 11140741 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.61 6.61

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL279377 1 6.61

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL279377 IC50 = 248.0 nM 6.61