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Assay Detail

CHEMBL754535

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Binding
Inhibitory potency evaluated against rat p38 kinase
ChEMBL ↗
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Mitogen-activated protein kinase 14 (CHEMBL4825) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Pyrroles and other heterocycles as inhibitors of p38 kinase.
de Laszlo SE, Visco D, Agarwal L, Chang L, Chin J, Croft G, Forsyth A, Fletcher D, Frantz B, Hacker C, Hanlon W, Harper C, Kostura M, Li B, Luell S, MacCoss M, Mantlo N, O'Neill EA, Orevillo C, Pang M, Parsons J, Rolando A, Sahly Y, Sidler K, O'Keefe SJ.
Bioorg Med Chem Lett (1998) 8 : 2689 -2694
PubMed 9873604 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 53 6.94 8.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL91630 — — 1 8.36
CHEMBL88486 — — 1 8.29
CHEMBL91934 — — 1 8.22
CHEMBL312942 — — 1 8.21
CHEMBL316275 — — 1 8.01
CHEMBL314219 — — 1 7.92
CHEMBL88904 — — 1 7.85
CHEMBL419128 — — 1 7.77
CHEMBL91568 — — 1 7.77
CHEMBL328150 — — 1 7.75
CHEMBL89428 — — 1 7.55
CHEMBL92440 — — 1 7.54
CHEMBL314731 — — 1 7.54
CHEMBL314162 — — 1 7.52
CHEMBL327911 — — 1 7.47
CHEMBL91730 — — 1 7.46
CHEMBL328318 — — 1 7.38
CHEMBL91652 — — 1 7.36
CHEMBL88546 — — 1 7.28
CHEMBL328148 — — 1 7.28
CHEMBL92498 — — 1 7.22
CHEMBL91648 — — 1 7.22
CHEMBL314238 — — 1 7.10
CHEMBL315863 — — 1 7.08
CHEMBL90169 — — 1 7.01
CHEMBL330563 — — 1 7.00
CHEMBL88844 — — 1 6.94
CHEMBL314761 — — 1 6.92
CHEMBL431216 — — 1 6.89
CHEMBL88325 — — 1 6.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL91630 — IC50 = 4.4 nM 8.36
CHEMBL88486 — IC50 = 5.1 nM 8.29
CHEMBL91934 — IC50 = 6.0 nM 8.22
CHEMBL312942 — IC50 = 6.1 nM 8.21
CHEMBL316275 — IC50 = 9.8 nM 8.01
CHEMBL314219 — IC50 = 12.0 nM 7.92
CHEMBL88904 — IC50 = 14.0 nM 7.85
CHEMBL419128 — IC50 = 17.0 nM 7.77
CHEMBL91568 — IC50 = 17.0 nM 7.77
CHEMBL328150 — IC50 = 18.0 nM 7.75
CHEMBL89428 — IC50 = 28.0 nM 7.55
CHEMBL92440 — IC50 = 29.0 nM 7.54
CHEMBL314731 — IC50 = 29.0 nM 7.54
CHEMBL314162 — IC50 = 30.0 nM 7.52
CHEMBL327911 — IC50 = 34.0 nM 7.47
CHEMBL91730 — IC50 = 35.0 nM 7.46
CHEMBL328318 — IC50 = 42.0 nM 7.38
CHEMBL91652 — IC50 = 44.0 nM 7.36
CHEMBL88546 — IC50 = 53.0 nM 7.28
CHEMBL328148 — IC50 = 53.0 nM 7.28
CHEMBL92498 — IC50 = 60.0 nM 7.22
CHEMBL91648 — IC50 = 60.0 nM 7.22
CHEMBL314238 — IC50 = 80.0 nM 7.10
CHEMBL315863 — IC50 = 83.0 nM 7.08
CHEMBL90169 — IC50 = 97.0 nM 7.01
CHEMBL330563 — IC50 = 100.0 nM 7.00
CHEMBL88844 — IC50 = 114.0 nM 6.94
CHEMBL314761 — IC50 = 120.0 nM 6.92
CHEMBL431216 — IC50 = 130.0 nM 6.89
CHEMBL88325 — IC50 = 200.0 nM 6.70
CHEMBL327390 — IC50 = 240.0 nM 6.62
CHEMBL91274 — IC50 = 260.0 nM 6.58
CHEMBL90373 — IC50 = 280.0 nM 6.55
CHEMBL91165 — IC50 = 390.0 nM 6.41
CHEMBL330292 — IC50 = 450.0 nM 6.35
CHEMBL330010 — IC50 = 500.0 nM 6.30
CHEMBL90341 — IC50 = 500.0 nM 6.30
CHEMBL328354 — IC50 = 510.0 nM 6.29
CHEMBL88925 — IC50 = 530.0 nM 6.28
CHEMBL91459 — IC50 = 630.0 nM 6.20
CHEMBL541213 — IC50 = 660.0 nM 6.18
CHEMBL315192 — IC50 = 690.0 nM 6.16
CHEMBL91540 — IC50 = 710.0 nM 6.15
CHEMBL91376 — IC50 = 910.0 nM 6.04
CHEMBL88538 — IC50 = 1220.0 nM 5.91
CHEMBL328126 — IC50 = 1400.0 nM 5.85
CHEMBL329889 — IC50 = 1700.0 nM 5.77
CHEMBL91721 — IC50 = 2300.0 nM 5.64
CHEMBL91196 — IC50 = 2400.0 nM 5.62
CHEMBL91331 — IC50 = 5000.0 nM 5.30