Assay Detail
Binding
CHEMBL754590
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Ability to displace [3H]nociceptin ( 0.5 nM ) binding from Opioid receptor like 1 expressed in HeLa cells.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-Aminoquinolines: novel nociceptin antagonists with analgesic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.86 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434060 | — | — | 1 | 8.74 |
| CHEMBL139776 | — | — | 1 | 8.74 |
| CHEMBL140640 | — | — | 1 | 8.74 |
| CHEMBL342580 | — | — | 1 | 8.66 |
| CHEMBL337128 | — | — | 1 | 8.64 |
| CHEMBL142454 | — | — | 1 | 8.59 |
| CHEMBL139934 | — | — | 1 | 8.19 |
| CHEMBL140103 | — | — | 1 | 8.15 |
| CHEMBL140979 | — | — | 1 | 8.09 |
| CHEMBL140519 | — | — | 1 | 7.93 |
| CHEMBL142999 | — | — | 1 | 7.88 |
| CHEMBL143605 | — | — | 1 | 7.69 |
| CHEMBL140580 | — | — | 1 | 7.43 |
| CHEMBL139566 | — | — | 1 | 7.33 |
| CHEMBL422641 | — | — | 1 | 7.08 |
| CHEMBL143243 | — | — | 1 | 7.07 |
| CHEMBL343424 | — | — | 1 | 7.05 |
| CHEMBL141078 | — | — | 1 | 6.92 |
| CHEMBL139816 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434060 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL139776 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL140640 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL342580 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL337128 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL142454 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL139934 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL140103 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL140979 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL140519 | — | Ki | = | 11.8 | nM | 7.93 |
| CHEMBL142999 | — | Ki | = | 13.2 | nM | 7.88 |
| CHEMBL143605 | — | Ki | = | 20.4 | nM | 7.69 |
| CHEMBL140580 | — | Ki | = | 37.3 | nM | 7.43 |
| CHEMBL139566 | — | Ki | = | 46.7 | nM | 7.33 |
| CHEMBL422641 | — | Ki | = | 82.4 | nM | 7.08 |
| CHEMBL143243 | — | Ki | = | 85.6 | nM | 7.07 |
| CHEMBL343424 | — | Ki | = | 88.5 | nM | 7.05 |
| CHEMBL141078 | — | Ki | = | 121.2 | nM | 6.92 |
| CHEMBL139816 | — | Ki | = | 369.3 | nM | 6.43 |