Assay Detail
Binding
CHEMBL754612
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Binding affinity to displace radioligand [3H]U-69593 on Opioid receptor kappa 1 in guinea pig membranes.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Selective protection and functionalization of morphine: synthesis and opioid receptor binding properties of 3-amino-3-desoxymorphine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.38 | 10.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56585 | CYCLAZOCINE | 2.0 | 1 | 10.28 |
| CHEMBL2367916 | — | — | 1 | 9.27 |
| CHEMBL2367918 | — | — | 1 | 8.92 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.62 |
| CHEMBL333965 | — | — | 1 | 6.62 |
| CHEMBL119332 | — | — | 1 | 6.54 |
| CHEMBL333959 | — | — | 1 | 6.13 |
| CHEMBL119692 | — | — | 1 | 5.55 |
| CHEMBL332927 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56585 | CYCLAZOCINE | Ki | = | 0.052 | nM | 10.28 |
| CHEMBL2367916 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL2367918 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL70 | MORPHINE | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL333965 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL119332 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL333959 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL119692 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL332927 | — | Ki | = | 3400.0 | nM | 5.47 |