Assay Detail
Binding
CHEMBL754613
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Binding affinity for kappa opioid receptor was measured using [3H]U-69593
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.83 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL348011 | — | — | 1 | 9.15 |
| CHEMBL149256 | — | — | 1 | 8.17 |
| CHEMBL346173 | — | — | 1 | 8.06 |
| CHEMBL357680 | — | — | 1 | 8.02 |
| CHEMBL356387 | — | — | 1 | 7.92 |
| CHEMBL346165 | — | — | 1 | 7.91 |
| CHEMBL146907 | — | — | 1 | 7.72 |
| CHEMBL150028 | — | — | 1 | 7.47 |
| CHEMBL567175 | NALTRINDOLE | — | 1 | 7.45 |
| CHEMBL356861 | — | — | 1 | 7.25 |
| CHEMBL358208 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL348011 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL149256 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL346173 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL357680 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL356387 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL346165 | — | Ki | = | 12.2 | nM | 7.91 |
| CHEMBL146907 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL150028 | — | Ki | = | 33.9 | nM | 7.47 |
| CHEMBL567175 | NALTRINDOLE | Ki | = | 35.8 | nM | 7.45 |
| CHEMBL356861 | — | Ki | = | 55.7 | nM | 7.25 |
| CHEMBL358208 | — | Ki | = | 92.0 | nM | 7.04 |