Assay Detail
Binding
CHEMBL754618
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Binding affinity towards guinea pig Opioid receptor kappa 1 using radioligand [3H]U-69593
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
3-Carboxamido analogues of morphine and naltrexone. synthesis and opioid receptor binding properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.05 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56585 | CYCLAZOCINE | 2.0 | 1 | 9.74 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 9.51 |
| CHEMBL56695 | — | — | 1 | 7.66 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.62 |
| CHEMBL47512 | — | — | 1 | 5.70 |
| CHEMBL50386 | — | — | 1 | - |
| CHEMBL49029 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56585 | CYCLAZOCINE | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL19019 | NALTREXONE | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL56695 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL70 | MORPHINE | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL47512 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL50386 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL49029 | — | Ki | > | 10000.0 | nM | - |