Assay Detail
Binding
CHEMBL754620
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Binding affinity towards opioid receptor kappa 1
9
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Phenylmorphans and analogues: opioid receptor subtype selectivity and effect of conformation on activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.07 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287726 | — | — | 3 | 7.31 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.31 |
| CHEMBL285250 | — | — | 2 | 7.01 |
| CHEMBL290855 | — | — | 1 | 6.96 |
| CHEMBL36707 | — | — | 1 | - |
| CHEMBL31421 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287726 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL70 | MORPHINE | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL287726 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL287726 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL285250 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL290855 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL285250 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL36707 | — | Ki | > | 500.0 | nM | - |
| CHEMBL31421 | — | Ki | > | 350.0 | nM | - |