Assay Detail
Binding
CHEMBL754638
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In vitro inhibition of purified rat kidney Neutral endopeptidase.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Dual metalloprotease inhibitors. 6. Incorporation of bicyclic and substituted monocyclic azepinones as dipeptide surrogates in angiotensin-converting enzyme/neutral endopeptidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.02 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299639 | — | — | 1 | 8.22 |
| CHEMBL434070 | — | — | 1 | 7.77 |
| CHEMBL41201 | — | — | 1 | 7.75 |
| CHEMBL39775 | — | — | 1 | 7.60 |
| CHEMBL146371 | — | — | 1 | 7.51 |
| CHEMBL357932 | — | — | 1 | 7.50 |
| CHEMBL147043 | — | — | 1 | 7.40 |
| CHEMBL104054 | — | — | 1 | 7.31 |
| CHEMBL148155 | — | — | 1 | 7.19 |
| CHEMBL299169 | — | — | 1 | 7.09 |
| CHEMBL149442 | — | — | 1 | 7.07 |
| CHEMBL144659 | — | — | 1 | 7.04 |
| CHEMBL146823 | — | — | 1 | 6.85 |
| CHEMBL318096 | — | — | 1 | 6.83 |
| CHEMBL287896 | — | — | 1 | 6.40 |
| CHEMBL343191 | — | — | 1 | 6.33 |
| CHEMBL356577 | — | — | 1 | 6.00 |
| CHEMBL345021 | — | — | 1 | 5.78 |
| CHEMBL147153 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299639 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL434070 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL41201 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL39775 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL146371 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL357932 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL147043 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL104054 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL148155 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL299169 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL149442 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL144659 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL146823 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL318096 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL287896 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL343191 | — | IC50 | = | 466.0 | nM | 6.33 |
| CHEMBL356577 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL345021 | — | IC50 | = | 1655.0 | nM | 5.78 |
| CHEMBL147153 | — | IC50 | = | 1653.0 | nM | 5.78 |