Assay Detail
Binding
CHEMBL754738
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Binding affinity of compound for Opioid receptor kappa 1 was determined using [3H]U-69593 as radioligand from guinea pig caudate
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Importance of phenolic address groups in opioid kappa receptor selective antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.46 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415247 | JDTIC | 1.0 | 1 | 9.49 |
| CHEMBL573214 | NORBINALTORPHIMINE | — | 2 | 8.96 |
| CHEMBL10872 | — | — | 1 | 8.68 |
| CHEMBL10986 | — | — | 1 | 8.42 |
| CHEMBL11285 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415247 | JDTIC | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL573214 | NORBINALTORPHIMINE | Ki | = | 1.09 | nM | 8.96 |
| CHEMBL573214 | NORBINALTORPHIMINE | Ki | = | 1.33 | nM | 8.88 |
| CHEMBL10872 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL10986 | — | Ki | = | 3.84 | nM | 8.42 |
| CHEMBL11285 | — | Ki | = | 446.0 | nM | 6.35 |